EFFECTS OF FCγRIIIA ON AORTIC ATHEROSCLEROTIC PLAQUE DESTABILISATION IN APOE−/− MICE
نویسندگان
چکیده
منابع مشابه
Dystrophin deficiency reduces atherosclerotic plaque development in ApoE-null mice
Dystrophin of the dystrophin-glycoprotein complex connects the actin cytoskeleton to basement membranes and loss of dystrophin results in Duchenne muscular dystrophy. We have previously shown injury-induced neointima formation of the carotid artery in mice with the mdx mutation (causing dystrophin deficiency) to be increased. To investigate the role of dystrophin in intimal recruitment of smoot...
متن کاملTryptase Promotes Atherosclerotic Plaque Haemorrhage in ApoE-/- Mice
Tryptase, the most abundant mast cell (MC) granule protein, plays an important role in atherosclerosis plaque development. To test the hypothesis that tryptase participates directly in atherosclerosis plaque haemorrhage, the gene sequence and siRNA for tryptase were cloned into a lentivirus carrier and atherosclerosis plaque haemorrhage models in ApoE-/- mice were constructed. After a cuffing-c...
متن کاملSimvastatin Promotes Atherosclerotic Plaque Stability in ApoE-Deficient Mice
Florian Bea, Erwin Blessing, Brian Bennett, Michael Levitz, Elizabeth P. Wallace and Michael Independently of Lipid Lowering Simvastatin Promotes Atherosclerotic Plaque Stability in ApoE-Deficient Mice Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2002 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Associa...
متن کاملA meprin inhibitor suppresses atherosclerotic plaque formation in ApoE-/- mice.
Meprin is a member of the astacin family of zinc metalloendopeptidases. It is widely distributed in the body, and hydrolyzes and inactivates several endogenous vasoactive peptides, some of which could alter various functions of cells in the arterial wall. We assessed the influence of chronic meprin inhibition by daily administration of actinonin (5mg/kg body weight per day; i.p.) on the develop...
متن کاملThrombospondin-1 deficiency accelerates atherosclerotic plaque maturation in ApoE-/- mice.
Thrombospondin (TSP)1 is implicated in various inflammatory processes, but its role in atherosclerotic plaque formation and progression is unclear. Therefore, the development of atherosclerosis was compared in ApoE(-/-) and Tsp1(-/-)ApoE(-/-) mice kept on a normocholesterolemic diet. At 6 months, morphometric analysis of the aortic root of both mouse genotypes showed comparable lesion areas. Ev...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Heart
سال: 2012
ISSN: 1355-6037,1468-201X
DOI: 10.1136/heartjnl-2012-302920a.177